In biological and medical sciences, high throughput analytical methods are now commonly used to investigate samples of different conditions, e.g., patients versus controls. Systemic functional analyses emerged as a reference method to go beyond a list of regulated compounds, and identify activated or inactivated biological functions. This approach holds the promise for a better understanding of biological systems, of the mechanisms involved in disease progression, and thus improved diagnosis, prognosis, and treatment. In this chapter, we present a simple workflow to conduct pathway analyses on biological data using the freely available Reactome platform (http://www.reactome.org)
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Sánchez, L. F. H., Aasebø, E., Selheim, F., Berven, F. S., Ræder, H., Barsnes, H., & Vaudel, M. (2016). Systemic analysis of regulated functional networks. In Methods in Molecular Biology (Vol. 1394, pp. 287–310). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3341-9_21
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