Hepcidin and Iron in Health and Disease

152Citations
Citations of this article
227Readers
Mendeley users who have this article in their library.

Abstract

Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores. Hepcidin concentration in plasma is increased by iron loading and inflammation and is suppressed by erythropoietic stimulation and during pregnancy. Hepcidin deficiency causes iron overload in hemochromatosis and anemias with ineffective erythropoiesis. Hepcidin excess causes iron-restrictive anemias including anemia of inflammation. The development of hepcidin diagnostics and therapeutic agonists and antagonists should improve the treatment of iron disorders.

Cite

CITATION STYLE

APA

Nemeth, E., & Ganz, T. (2023, January 27). Hepcidin and Iron in Health and Disease. Annual Review of Medicine. Annual Reviews Inc. https://doi.org/10.1146/annurev-med-043021-032816

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free