Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites

Abstract

Anvillea garcinii (AG, Asteraceae) commonly called "nougd" in Arabic is traditionally used for the treatment of different gastrointestinal disorders. This study evaluates the effects of ethanol, chloroform and n-butanol extracts of AG on ulcerative colitis induced by various ulcerogens in rats and the isolation of new secondary metabolites. Ethanol extracts of the leaf of the AG demonstrated a powerful anti-ulcer activity which could be attributed to the synergistic effect of its constituents. Therefore, our results would be the first proof of traditional use of AG as an antiulcer ailment.