Factors influencing health-related quality of life in patients with Type 1 diabetes

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Abstract

Aims: Generic, preference-based measures of health-related quality of life (HRQoL) are a common input to the economic evaluation of new healthtechnologies. As such, it is important to explore what characteristics of patients with Type 1 diabetes might impact scores on such measures. Methods: This study utilizes baseline data from a cluster-randomized trial that recruited patients with Type 1 diabetes at six centers across Ireland. Health-related quality of life was assessed using the three-level EuroQol EQ-5D (EQ-5D) measure. Patients' responses to individual dimensions of the EQ-5D were explored. To see which patient factors influenced EQ-5D scores, multivariate regression analysis was conducted with EQ-5D scores as the outcome variable. Results: Data was available for 437 Type 1 diabetes patients. The median age of these patients was 40 (IQR: 31-49) years and 53.8% were female. Overall, patients reported a high HRQoL based on EQ-5D scores (0.87 (SD: 0.19). Fifty-four percent of patients reported a perfect HRQoL. For those that reported problems, the most common dimension was the anxiety/depression dimension of the EQ-5D (29.6%). In the multivariate regression analysis, self-reported mental illness (-0.22 (95% CI: -0.34, -0.10)) and being unemployed (-0.07 (95% CI: -0.13, -0.02)) were negatively associated with EQ-5D scores (p<0.05). The influence of self-reported mental illness was persistent in sensitivity analyses. Conclusions: The study results indicate that patients with Type 1 diabetes report a high HRQoL based on responses to the EQ-5D. However, there are a substantial number of Type 1 diabetes patients that report problems in the anxiety/depression dimension, which may provide avenues to improve patients' HRQoL.

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Raymakers, A. J. N., Gillespie, P., O’Hara, M. C., Griffin, M. D., & Dinneen, S. F. (2018). Factors influencing health-related quality of life in patients with Type 1 diabetes. Health and Quality of Life Outcomes, 16(1). https://doi.org/10.1186/s12955-018-0848-4

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