Is cystatin C a good predictor of acute kidney injury after elective aortic surgery?

Abstract

Background/Aim. Acute kidney injury (AKI) is a frequent and serious complication after aortic surgery, which increas-es the length of hospital stay, costs, morbidity, and mortali-ty. The aim of the study was to investigate the incidence of AKI and the most important preoperative and intraopera-tive predictive factors for AKI 72 hrs after elective infrare-nal aortic surgery (IAS). Methods. This prospective obser-vational study was performed at the Clinic of Anesthesia, Intensive Care and Pain Therapy, University Clinical Center of Vojvodina (UCCV), from October 2017 to April 2019. It included 140 adult patients who underwent an elective IAS. The occurrence of AKI was noted according to the Acute Kidney Injury Network (AKIN) criteria. A multivariate lo-gistic regression model was used for potential predictive fac-tors. Results. The incidence of AKI after the elective IAS at the Clinic of Anesthesia, Intensive Care and Pain Thera-py, UCCV, was 28.56%. According to the receiver operating characteristic (ROC) curve analysis, the cut-off value of cys-tatin C serum concentration of 1.14 mg/L had the highest sensitivity (82.5%) and specificity (76%) in the differentia-tion of patients who will develop AKI. The final model contained the following variables: the presence of chronic kidney disease, the preoperative serum concentration of cys-tatin C > 1.14 mg/L, the application of colloid solutions in volume > 500 mL during the operation, and the total intra-vascular fluid replacement volume > 59 mL/kg in the in-traoperative period. Conclusion. The incidence of AKI at the Clinic of Anesthesia, Intensive Care and Pain Therapy, UCCV, is somewhat higher compared to the literature data. A presurgical value of cystatin C above 1.14 mg/L is a good predictor of AKI after the elective IAS.