We describe tactics to assess pharmacokinetic (PK) and pharmacodynamic (PD) parameters of oligonucleotides. The chapter includes recommendations on the design of single-dose preclinical PK studies, preclinical PKPD studies, and toxicological studies, and on best practice for scaling PK and PD parameters from animal to human. We focus on single-stranded oligonucleotides, but relevant differences to double-stranded RNAs are also addressed.
CITATION STYLE
Jansson-Löfmark, R., Ahlström, C., & Gennemark, P. (2019). ADME: Assessing Pharmacokinetic–Pharmacodynamic Parameters of Oligonucleotides. In Methods in Molecular Biology (Vol. 2036, pp. 317–339). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9670-4_19
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