Directed nucleophilic addition of phenoxides to cyclopropenes

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Abstract

The alkali metal-templated addition of aryloxides across the double bond of non-conjugated cyclopropenes is described. High cis-selectivity is achieved through a directing effect of a strategically positioned carboxamide functionality.

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Yamanushkin, P., Lu-Diaz, M., Edwards, A., Aksenov, N. A., Rubina, M., & Rubin, M. (2017). Directed nucleophilic addition of phenoxides to cyclopropenes. Organic and Biomolecular Chemistry, 15(38), 8153–8165. https://doi.org/10.1039/c7ob01785e

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