Sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) with a pore size of 6 nm was synthesized using surface modification of Santa Barbara Amorphous (SBA-15). It is a solid acid hexagonally nano-reactor with high surface area and is reusable, high selective, non-corrosiveness which can easily isolate from the products. An efficient and green one-pot three component reaction was developed for the synthesis of pyrido[2,3-d]pyrimidine derivatives via a simple, mild and effective solvent free reaction of 4(6)-aminouracil, barbituric acid and aromatic aldehydes in the presence using SBA-Pr-SO3H. In this reaction, SBA-Pr-SO3H was an effective nano-catalyst which gave the products in good to high yields in a shorter reaction time compared to the other published reports. Some of the products were strong antibiotics against Bacillus subtilis and Staphylococcus aureus.
CITATION STYLE
Ziarani, G. M., Gholamzadeh, P., Badiei, A., Asadi, S., & Soorki, A. A. (2015). Application of SBA-15 functionalized sulfonic acid (SBA-Pr-SO3H) as an efficient nanoreactor in the one-pot synthesis of pyrido[2,3-d]pyrimidine. Journal of the Chilean Chemical Society, 60(2), 2975–2978. https://doi.org/10.4067/S0717-97072015000200024
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