Glutamine-cycling pathway in metabolic syndrome: Systems biology-based characterization of the glutamate-related metabolotype and advances for diagnosis and treatment in translational medicine

Abstract

In this chapter we introduce the hypothesis that the glutamine-cycling pathway participates in the pathogenesis of MS and might be prominently involved in the development of the systemic underlying metabolic derangement. In addition, we postulate the critical role that some enzymatic reactions occurring in the liver tissue, such as the transamination reactions, play in the pathogenesis of MS.