Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

Abstract

Background: Exosomes can transfer information between cells and facilitate tumor development. Results: PC12 cell-derived exosomes enter into BMSCs through clathrin-mediated endocytosis and macropinocytosis, and decrease the expression of TGFβRII and TPM1 through miR-21. Conclusion: The results dissect the pathway of exosome internalization and demonstrate their regulation ability. Significance: These findings enhanced our knowledge of the internalization and function of tumor exosomes. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.