Human colostrum contains IgA antibodies reactive to colonization factors I and II of enterotoxigenic Escherichia coli

10Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

Abstract

Diarrhea is an important cause of morbidity and mortality amongst infants of low socio-economic levels in developing countries and in travelers who visit such areas. Enterotoxigenic E. coli strains express two sets of virulence-associated factors: enterotoxins (heat-stable toxins or heat-labile toxins) and colonization factors. Studies have shown that breast-feeding protects infants against infectious diseases, such as diarrhea, as it presents a great variety of immunological components. The aim of this study was to analyze the reactivity of immunoglobulin A from human colostrum to colonization factor antigens I and II. The colostrum ability in preventing enterotoxigenic E. coli adhesion to Caco-2 cells was also evaluated. Colostrum samples were collected from 32 healthy women, and a human colostrum pool was prepared. Enterotoxigenic E. coli strains expressing colonization factor antigens I and II were utilized. The colostrum pool and individual samples showed variable antienterotoxigenic E. coli immunoglobulin A titers, that were reactive with colonization factor antigen I and CS1/CS3 (colonization factor antigen II). The human colostrum pool and individual samples inhibited enterotoxigenic E. coli colonization factor antigen I and II adhesion to Caco-2 cells, at variable levels, and this ability was a result of immunoglobulin A antibodies reactive to these colonization factors. The immunoglobulin A-depleted pool lost this inhibitory ability. As bacterial adhesion is the initial mechanism of enterotoxigenic E. coli infection, breast-feeding could protect the offspring against diarrhea caused by this agent. © 2006 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

Cite

CITATION STYLE

APA

Corrêa, S., Palmeira, P., Carneiro-Sampaio, M. M. S., Sanae Nishimura, L., & Guth, B. E. C. (2006). Human colostrum contains IgA antibodies reactive to colonization factors I and II of enterotoxigenic Escherichia coli. FEMS Immunology and Medical Microbiology, 47(2), 199–206. https://doi.org/10.1111/j.1574-695X.2006.00082.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free