A new model of chronic peripheral nerve compression for basic research and pharmaceutical drug testing

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Abstract

Aim: To develop a consistent model to standardize research in the field of chronic peripheral nerve neuropathy. Methods: The left sciatic nerve of 8-week-old Sprague-Dawley rats was compressed using a customized instrument leaving a defined post injury nerve lumen (400 μm, 250 μm, 100 μm, 0 μm) for 6 weeks. Sensory and motor outcomes were measured weekly, and histomorphology and electrophysiology after 6 weeks. Results: The findings demonstrated compression depth-dependent sensory and motor pathologies. Quantitative measurements revealed a significant myelin degeneration, axon irregularities and muscle atrophy. At the functional level, we highlighted the dynamics of the different injury profiles. Conclusion: Our novel model of chronic peripheral nerve compression is a useful tool for research on pathophysiology and new therapeutic approaches.

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Degrugillier, L., Prautsch, K. M., Schaefer, D. J., Guzman, R., Schären, S., Kalbermatten, D. F., & Madduri, S. (2021). A new model of chronic peripheral nerve compression for basic research and pharmaceutical drug testing. Regenerative Medicine, 16(10), 931–947. https://doi.org/10.2217/rme-2020-0129

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