The radiobiology of accelerated partial breast irradiation

Abstract

This chapter focuses on the radiobiology of breast cancer and the radiobiological principles that underpin APBI. The linear quadratic (LQ) equation is the radiobiological model most commonly used to compare the effects of different dose and fractionation schedules. Within this model, there are two assumed components of radiation damage, characterized by radiosensitivity coefficients α and β. The calculated values of α/β specific to breast cancer are presented. In addition to the general radiobiology of APBI, the radiobiological principles specifically related to the most commonly used APBI techniques are discussed. Understanding these principles enables a more informed prediction of disease control and toxicity, and enables quantitative comparison between techniques and regimes. © 2009 Springer Berlin Heidelberg.