Regulation of TFPI function by protein S

56Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Protein S is an anticoagulant cofactor of full-length tissue factor pathway inhibitor (TFPI) that facilitates optimal factor Xa-inhibition and efficient down-regulation of thrombin generation in plasma. Protein S and TFPI are constitutively active in plasma and therefore provide an effective anticoagulant barrier against unwanted procoagulant activity in the circulation. In this review, we describe the current status on how TFPI-activity depends on protein S, and show that TFPI and protein S are major regulators of thrombin generation both in the absence and presence of activated protein C (APC). As there is covariation of plasma TFPI and protein S levels both in health and in disease, these findings suggest that the risk of venous thrombosis associated with protein S deficiency states might be in part explained by the accompanying low plasma TFPI levels. © 2009 International Society on Thrombosis and Haemostasis.

Author supplied keywords

Cite

CITATION STYLE

APA

Hackeng, T. M., Maurissen, L. F. A., Castoldi, E., & Rosing, J. (2009). Regulation of TFPI function by protein S. Journal of Thrombosis and Haemostasis. https://doi.org/10.1111/j.1538-7836.2009.03363.x

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free