Peroxisome proliferator-activated receptor-γ coactivator-1α polymorphism is not associated with essential hypertension and type 2 diabetes mellitus in Chinese population

Abstract

To investigate whether variations in the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) are associated with essential hypertension and type 2 diabetes in a Chinese population. A case-control study design was applied in a Chinese population. Two single nucleotide polymorphisms (SNPs), +1302G> A and G482S, in the PGC-1α gene were genotyped and compared between 494 unrelated Chinese subjects with essential hypertension and type 2 diabetes and 555 normal control subjects with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. These two polymorphisms were in highly significant linkage disequilibrium with each other (p<0.0001). The frequency of the 482S allele was 42.9% in the Chinese population, which was similar to the frequency in the Japanese population (43.7%), but much higher than those of Caucasian populations (30.8% to 38.1%). There were no associations of the G482S and +1302G>A polymorphisms and haplotype combinations with essential hypertension and type 2 diabetes. In addition, no associations were found between these two polymorphisms and blood pressure. In conclusion, these results indicated that these two variations in the PGC-1α gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.