Forças mecânicas e veias safenas humanas: Implicaç ão na revascularização do miocárdio

Abstract

Vascular endothelial cells are exposed to a variety of in vivo mechanical forces, specifically, shear stress due to blood flow, tensile stress from the compliance of the vessel wall and hydrostatic pressure from containment of blood within the vessel. Many authors studied hemodynamic, functional and morphological human saphenous vein alterations caused by these different forces with conflicting results. This review was motivated with the specific aim of analyzing published data and presenting some experimental data from our laboratory. The adopted review subjects were: 1) Endothelial response and gene regulation to shear stress; 2) Effects of hydrostatic pressure on the endothelial cell morphology, gene expression of the endothelial cellular surface and proliferation of endothelial cells; 3) Effects of traction on the human saphenous vein endothelium.