γδ T cells: Crosstalk between microbiota, chronic inflammation, and colorectal cancer

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Abstract

Increasing evidence suggests that intestinal microbiota dysbiosis and chronic inflammation contribute to colorectal cancer (CRC) development. γδ T cells represent a major innate immune cell population in the intestinal epithelium that is involved in the maintenance of gut homeostasis, inflammation regulation, and carcinogenesis. The important contributions of γδ T cells are (i) to perform a protective role in the context of barrier damage and pathogenic microorganism translocation; (ii) to exert either pro- or anti-inflammatory effects at different inflammatory stages; and (iii) to boost the crosstalk between immune cells and tumor microenvironment, inducing a cascade of suppressive immune responses. Understanding the crucial role of γδ T cells would enable us to manipulate these cells during the CRC sequence and improve the efficacy of tumor therapy.

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Yang, Y., Xu, C., Wu, D., Wang, Z., Wu, P., Li, L., … Qiu, F. (2018). γδ T cells: Crosstalk between microbiota, chronic inflammation, and colorectal cancer. Frontiers in Immunology, 9(JUN). https://doi.org/10.3389/fimmu.2018.01483

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