Derangement in lipid profile in nephrotic syndrome in children

Abstract

Background: Hyperlipidemia, an important characteristic of idiopathic nephrotic syndrome in children (NS),thereby makes them prone to develop premature atherosclerosis and related complications.Methods: We have investigated the changes in different fractions of lipids and apolipoproteins level in thirtychildren of 1-12 years of age with idiopathic nephrotic syndrome. Twenty-six age and sex matched hospitalizedchildren, suffering from non-renal diseases, were enrolled as controls.Results: The results revealed that ApoB along with cholesterol, triglyceride and LDL-cholesterol, were significantly increased (p<0.001), whereas apoA1 and HDL-cholesterol were unaltered in the patients compared to the controls. Further, the ratios cholesterol: HDL-cholesterol, triglyceride: HDL-cholesterol and LDL cholesterol: HDL-cholesterol were also increased (p<0.001) and apoA1: apoB were lowered (p<0.001) in patients of nephrotic syndrome.Conclusions: Therefore, there is a need to evaluate the lipid and lipoprotein levels early and so that appropriate therapy can be offered to selective candidates.