Deficit of magnesium and states of hypercoagulation: Intellectual analysis of data obtained from a sample of patients aged 18-50 years from medical and preventive facilities in Russia

Abstract

The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio-and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients. Aim: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia. Methods. The analysis was realized as analysis of data obtained in a cross-sectional study. In the cohort of patients (n=1453) formed from the IMBD adequacy of Mg supply was assessed by magnesium levels in blood plasma (Mg BP) (0.69±0.15 mmol / L) and estimates of daily Mg consumption according to dietary diaries (Mg D) (185±90 mg / day). Results. Mg supply was adequate (Mg BP >0.80 mmol / L, Mg D >300 mg / day) in not more than 6 % of patients. Presence of "Hypercoagulation" label in data base was associated with greater number of chronic diseases (2.3±2.1 and 0.83±0.8 with and without this label, respectively, p=0.0006) and elevated risk of the presence on 4 comorbid pathologies (odds ratio [OR] 18, 95 % confidence interval [CI] 10-25, p=0.0006). Mg deficit (Mg BP <0.70 mmol / L) was associated with hypercoagulable states (OR 5.42, 95 % CI 1.83-16, p=0.0006), neurologic pathologies (partial epilepsy, vertigo, alcohol dependence syndrome, obsessive-compulsive disorder) and pathologies related to chronic inflammation (ulcerative colitis, allergy, ischemic heart disease). Blood hypercoagulation was associated with prescription of drugs capable to provoke hypercoagulable states and simultaneously Mg deficit: androgens and anabolic steroids (OR 4.00, 95 % CI 1.88-8.50, p=0.00008), immunodepressants (OR 5.16, 95 %CI 1.96-13.58, p=0.0002), tetracyclic antidepressants (OR 4.47, 95 %CI 1.54-13, p=0.0026), estrogen containing oral contraceptives (OR 3.3, 95 %CI 1.5-6.2, p=0.0028), and antibiotics (OR 1.80, 95 %CI 1-3.36, p=0.058). Lowered Mg BP levels were associated with augmented sensation of pain, lowering of efficacy of analgesia, and with more pronounced cutaneous lesions. Conclusion. Thus, regular intake of magnesium preparations is indicated for the vast majority of adult patients in medico-preventive facilities especially to those with hypercoagulation and polypragmasy.