Preparing a DNA-encoded chemical library platform is a major undertaking, which requires careful planning. Here we outline general design principles for DNA-encoded libraries on the levels of library topology, chemical reactions, and selection of building blocks. The effects of design parameters on the coverage of the chemical space by a DNA-encoded library and on the properties of encoded compounds are discussed.
CITATION STYLE
Zhang, Y., & Franzini, R. M. (2022). Design Considerations in Constructing and Screening DNA-Encoded Libraries. In Topics in Medicinal Chemistry (Vol. 40, pp. 123–143). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/7355_2022_147
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