Abstract
In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of 26.5 μM, while the IC50 of quercetin (the reference compound) was 38.1 μM. Compounds 7b, 7e, 7h showed certain scavenging activities for both types of free radicals.
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Yang, L., Gong, J., Wang, F., Zhang, Y., Wang, Y., Hao, X., … Zhao, Y. (2006). Synthesis and antioxidant evaluation of novel silybin analogues. Journal of Enzyme Inhibition and Medicinal Chemistry, 21(4), 399–404. https://doi.org/10.1080/14756360600682152
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