This chapter outlines the experimental methods for inducing Depression-like behavior in mice by separating group-housed mice to individual housing. This is a model of loneliness in mice. Loneliness-induced depression is measured using the forced swim test (FST) and tail suspension test (TST). The first part of the chapter describes the methods for inducing separation-induced depression. It summarizes the experimental protocols including behavioral testing of the animals. The second part describes some of the issues to be concerned within this paradigm. An up-to-date collection of protocols and procedures for troubleshooting are provided. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Brown, R. E., Martin, A. L., & Gunn, R. K. (2011). Separation-induced depression in the mouse. Neuromethods, 63, 235–250. https://doi.org/10.1007/978-1-61779-313-4_15
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