Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis

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Abstract

The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.

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Barr, G. D., Hudson, M. J., Priddle, J. D., & Jewell, D. P. (1987). Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis. Gut, 28(2), 186–189. https://doi.org/10.1136/gut.28.2.186

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