The antibiotic resistance survey: A preliminary report on the drug utilization evaluation study at the University Teaching Hospital, Charles University, Czech Republic

Abstract

Purpose - To perform a longitudinal drug utilization evaluation and to analyse the antibiotic resistance patterns of Pseudomonas aeruginosa as well as the consumption of selected antibiotics. Methods - Data from 1992-1997 were collected from the Hospital Pharmacy database at the University Teaching Hospital (1200 beds) where physicians' prescriptions are recorded. To analyse antibiotic consumption, ATC/DDD methodology was used. To express the dynamics of the drug consumption, the value of index I was established. To analyse the resistance patterns of Pseudomonas aeruginosa, data from the antibiotic centre database at The Teaching Hospital were examined. Results - The rate of consumption is on the rise among extend spectrum aminopenicillins, carbapenems, glycopeptides, third generation cephalosporins and second generation macrolides and fluoroquinolones. Antibiotics with a decline in the rate of consumption are first generation macrolides and tetracyclines. Conclusions - The consumption of relatively new and expensive antibiotics increased during the observation period between 1992-1997. Resistance of Pseudomonas aeruginosa to selected antibiotics was identified to be increasing. In the case of amikacin and ceftazidime a possible association between resistance and consumption was found. Copyright (C) 2000 John Wiley and Sons, Ltd.