Molecular mechanisms of heavy metal toxicity in cancer progression

Abstract

In last few years, cancer became one of the leading cause of death in humans. There are several factors associated with the cancer initiation and progression including heavy metals. Several heavy metals including arsenic, cadmium, uranium, lead, mercury etc. and heavy metal-containing compounds are toxic to the humans and have been reported to induce mutations in human genome which further leads to the carcinogenesis. This chapter provides the detail understanding of molecular mechanisms and pathway analysis to heavy metal toxicity in human carcinogenesis.