Abstract
Introduction of the 2',4'-BNA monomer into oligonucleotides significantly enhanced binding affinity toward ssRNA and resistance to nuclease degradation. Here, we evaluated the antisense activity of 2',4'-BNA oligonucleotides against bcl-xL in HepG2 cells. Our data revealed that 2',4'-BNA antisense oligonucleotides remarkably inhibited the expression of bcl-xL in HepG2 cells compared to the natural DNA antisense oligonucleotide. The inhibitory effect of 2',4'-BNA antisense oligonucleotide was dose-dependent and highly sequence-specific.
Cite
CITATION STYLE
Roongjang, S., Takahashi, K., Park, M., Obika, S., & Imanishi, T. (2006). Antisense activity of 2’,4’-BNA targeted to bcl-xL gene in HepG2 cell. Nucleic Acids Symposium Series (2004), (50), 289–290. https://doi.org/10.1093/nass/nrl144
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
