Inhibition of xanthine oxidoreductase (XOR) has proven beneficial in a plethora of inflammatory disease processes due to a net reduction in pro-inflammatory oxidants and secondary nitrating species. Electrophilic nitrated fatty acid derivatives, such as nitro-oleic acid (OA-NO2) are also noted to display a broad spectrum of anti-inflammatory effects via interaction with critical signaling pathways. An alternative process in which nitrated fatty acids may extend anti-inflammatory actions is via inactivation of XOR, a process that is more effective than allo/oxypurinol-mediated inhibition. Herein, we describe the molecular aspects of nitrated fatty acid-associated inactivation of XOR, identify specificity via structure function relationships and discuss XOR as a crucial component of the anti-inflammatory portfolio of nitrated fatty acids.
CITATION STYLE
Kelley, E. E. (2019). Diminishing inflammation by reducing oxidant generation: Nitrated fatty acid-mediated inactivation of xanthine oxidoreductase. In Advances in Experimental Medicine and Biology (Vol. 1127, pp. 59–65). Springer New York LLC. https://doi.org/10.1007/978-3-030-11488-6_4
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