Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy. © 2012 BioMed Central Ltd.
CITATION STYLE
Ochnik, A. M., & Yee, D. (2012). Estrogen-related receptor alpha: An orphan finds a family. Breast Cancer Research, 14(3). https://doi.org/10.1186/bcr3124
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