The paucity of pathogenic T cells in circulating blood limits the information delivered by bulk analysis. Toward diagnosis and monitoring of treatments of autoimmune diseases, we have devised single-cell analysis approaches capable of identifying and characterizing rare circulating CD4 T cells.
CITATION STYLE
Holt, M., Costanzo, A., Gioia, L., Abe, B., Su, A. I., & Teyton, L. (2018). Gene profiling and T cell receptor sequencing from antigen-specific CD4 T cells. In Methods in Molecular Biology (Vol. 1712, pp. 217–238). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7514-3_14
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