Idiopathic Diffuse Hyperplasia of Pulmonary Neuroendocrine Cells and Airways Disease

  • Aguayo S
  • Miller Y
  • Waldron J
  • et al.
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Abstract

IN contrast to fetal lungs, in which neuroendocrine cells are abundant and are thought to play a part in the paracrine regulation of lung development, normal adult lungs contain few neuroendocrine cells.123456However, neuroendocrine-cell hyperplasia is frequently observed in subjects living at high altitude7and in association with various lung diseases, particularly among cigarette smokers.8910111213Although the role of neuroendocrine cells in these conditions remains unclear, it is speculated that hyperplasia of pulmonary neuroendocrine cells is an adaptive response to hypoxia7or a secondary process associated with chronic lung disease.789101112Recent investigations suggest, however, that alterations in neuroendocrine-cell physiology may… © 1992, Massachusetts Medical Society. All rights reserved.

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Aguayo, S. M., Miller, Y. E., Waldron, J. A., Bogin, R. M., Sunday, M. E., Staton, G. W., … King, T. E. (1992). Idiopathic Diffuse Hyperplasia of Pulmonary Neuroendocrine Cells and Airways Disease. New England Journal of Medicine, 327(18), 1285–1288. https://doi.org/10.1056/nejm199210293271806

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