Theoretical model of membrane protrusions driven by curved active proteins

7Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Eukaryotic cells intrinsically change their shape, by changing the composition of their membrane and by restructuring their underlying cytoskeleton. We present here further studies and extensions of a minimal physical model, describing a closed vesicle with mobile curved membrane protein complexes. The cytoskeletal forces describe the protrusive force due to actin polymerization which is recruited to the membrane by the curved protein complexes. We characterize the phase diagrams of this model, as function of the magnitude of the active forces, nearest-neighbor protein interactions and the proteins’ spontaneous curvature. It was previously shown that this model can explain the formation of lamellipodia-like flat protrusions, and here we explore the regimes where the model can also give rise to filopodia-like tubular protrusions. We extend the simulation with curved components of both convex and concave species, where we find the formation of complex ruffled clusters, as well as internalized invaginations that resemble the process of endocytosis and macropinocytosis. We alter the force model representing the cytoskeleton to simulate the effects of bundled instead of branched structure, resulting in shapes which resemble filopodia.

Cite

CITATION STYLE

APA

Ravid, Y., Penič, S., Mimori-Kiyosue, Y., Suetsugu, S., Iglič, A., & Gov, N. S. (2023). Theoretical model of membrane protrusions driven by curved active proteins. Frontiers in Molecular Biosciences, 10. https://doi.org/10.3389/fmolb.2023.1153420

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free