Trigonella-foenum graecum l. seed mucilage-based mucoadhesive microspheres of diclofenac sodium

Abstract

The study was aimed to discover the properties of Trigonella foenum graecum L. seed mucilage (TFGSM) in the formulation of mucoadhesive microspheres of diclofenac sodium to prolong the residence time at site of absorption. The effects of polymer ratios (TFGSM to sodium alginate) on drug encapsulation efficiency (DEE, %), mucoadhesivity, swelling index and cumulative drug release (CDR, %) over 8 h was investigated. TFGSM-based mucoadhesive microspheres of diclofenac sodium were prepared by employing ionotropic gelation technique. Different polymer ratios of TFGSM and sodium alginate were used to formulate eight formulations (F1 to F8) of TFGSM-based mucoadhesive microspheres of diclofenac sodium and characterized by determining its percentage yield and evaluating DEE (%), mucoadhesivity, swelling properties and CDR (%). The DEE (%) of all eight formulations was within the range of 77.97 to 98.05% with sustained in vitro release of over 8 h. The in vitro drug release of these microspheres followed controlled release (zero-order). The microspheres possessed good swelling properties and mucoadhesive properties.