Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals via bidirectional C-H insertion under Rh(ii) catalysis. Using a chiral Rh(ii) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).
CITATION STYLE
Lepage, R. J., White, J. M., & Coster, M. J. (2017). A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C-H insertion. Chemical Communications, 53(30), 4219–4221. https://doi.org/10.1039/c7cc00459a
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