Non-Viral Delivery of Gene Therapy to the Tendon

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Abstract

The tendon, as a compact connective tissue, is difficult to treat after an acute laceration or chronic degeneration. Gene-based therapy is a highly efficient strategy for diverse diseases which has been increasingly applied in tendons in recent years. As technology improves by leaps and bounds, a wide variety of non-viral vectors have been manufactured that attempt to have high biosecurity and transfection efficiency, considered to be a promising treatment modality. In this review, we examine the unwanted biological barriers, the categories of applicable genes, and the introduction and comparison of non-viral vectors. We focus on lipid-based nanoparticles and polymer-based nanoparticles, differentiating between them based on their combination with diverse chemical modifications and scaffolds.

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Jin, J., Yang, Q. Q., & Zhou, Y. L. (2022, August 1). Non-Viral Delivery of Gene Therapy to the Tendon. Polymers. MDPI. https://doi.org/10.3390/polym14163338

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