(Dis)solving the stroke problem by vWF inhibition?

Abstract

In this issue of Blood, Momi et al demonstrate that inhibition of the Glycoprotein Ib (GPIb)–von Willebrand factor (vWF) interaction dissolves newly formed intracranial vessel-occluding thrombi and reduces brain infarct size without increasing intracerebral hemorrhage in an experimental stroke model in guinea pigs.1