A study of maternally derived measles antibody in infants born to naturally infected and vaccinated women

60Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

Maternal, cord and infant measles antibody levels were measured and compared in a group of 411 vaccinated mothers and 240 unvaccinated mothers, and their babies, between 1983 and 1991. Maternal and cord sera were tested by haemagglutination inhibition and/or enzyme-linked immunosorbent assay, and plaque reduction neutralization tests were also used to test infant sera. Geometric mean titres were significantly higher in the unvaccinated than in the vaccinated mothers (P < 0.001). Infants born to mothers with a history of measles had higher antibody levels at birth than infants of vaccinated mothers and, although the difference narrowed over time, continued to have higher levels up to 30 weeks of age. Between 5 and 7 months of age significantly more of the children of vaccinated mothers had plaque reduction neutralization antibody levels below that which would interfere with vaccination. As the boosting effect of circulating natural measles disappears, earlier measles vaccination may need to be considered, perhaps as part of a two-dose policy.

References Powered by Scopus

Measles antibody: Reevaluation of protective titers

554Citations
N/AReaders
Get full text

Persistence of maternal antibody in infants beyond 12 months: Mechanism of measles vaccine failure

337Citations
N/AReaders
Get full text

Role of virus strain dm conventional and enhanced measles plaque neutralization test

176Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Early waning of maternal measles antibodies in era of measles elimination: Longitudinal study

223Citations
N/AReaders
Get full text

Factors determining prevalence of maternal antibody to measles virus throughout infancy: A review

149Citations
N/AReaders
Get full text

Passive transmission and persistence of naturally acquired or vaccine-induced maternal antibodies against measles in newborns

119Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Brugha, R., Ramsay, M., Forsey, T., & Brown, D. (1996). A study of maternally derived measles antibody in infants born to naturally infected and vaccinated women. Epidemiology and Infection, 117(3), 519–524. https://doi.org/10.1017/S0950268800059203

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 14

47%

Researcher 13

43%

Professor / Associate Prof. 2

7%

Lecturer / Post doc 1

3%

Readers' Discipline

Tooltip

Medicine and Dentistry 17

68%

Agricultural and Biological Sciences 3

12%

Psychology 3

12%

Social Sciences 2

8%

Save time finding and organizing research with Mendeley

Sign up for free