Successful treatment of a noninhibitory antibody‐mediated acquired factor X deficiency in a patient with marginal‐zone lymphoma

  • Meenhuis A
  • van Vliet R
  • Hudig F
  • et al.
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Abstract

Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B‐cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder.

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Meenhuis, A., van Vliet, R., Hudig, F., Ypma, P. F., Schipperus, M. R., & Hollestelle, M. J. (2015). Successful treatment of a noninhibitory antibody‐mediated acquired factor X deficiency in a patient with marginal‐zone lymphoma. Clinical Case Reports, 3(7), 587–593. https://doi.org/10.1002/ccr3.294

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