A phase II study of the cell cycle checkpoint kinases 1 and 2 (CHK1/2) inhibitor (LY2606368; prexasertib) in sporadic triple negative breast cancer (TNBC)

Abstract

Methods: Eligible pts have recurrent TNBC with no deleterious germline BRCA mutation or no family history of hereditary breast and ovarian cancer syndrome; good end organ function and safely biopsiable disease. Prexasertib was administered at 105 mg/m2 IV once every 14 days on a 28-day cycle. Response was assessed every 2 cycles by RECISTv1.1 and safety by CTCAEv4 per cycle. Primary endpoint is overall response rate (ORR). Optimal two- stage design was used; if ≥1 response is seen in the first 9 pts, then accrual continues to 24 pts per cohort.