Papulacandins, A New Family Of Antibiotics With Antifungal Activity: I. Fermentation, Isolation, Chemical And Biological Characterization Of Papulacandins A, B, C, D And E

Abstract

Papulacandin, a new antibiotic complex, active against Candida albicans and several other yeasts, was isolated from a strain of Papularia sphaerosperma. The fermentation, isolation, physico-chemical properties and biological activity of the five structurally related papulacandins A, B, C, D and E are reported. Papulacandin B, the main component, was assigned the formula of C47He4017. © 1977, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.