Platelet heterogeneity

Abstract

The heterogeneity of platelets is present at rest, upon stimulation by agonists, and within the hemostatic plug. Circulating platelets are heterogeneous in size, age, and responsiveness. Differences in platelet size, platelet age, and platelet genetics can result in variable reactivity and altered interactions of platelets both within and between individuals. Following stimulation by strong agonists, distinct activated platelet subpopulations of spread and aggregating platelets and procoagulant platelets can be identified. Procoagulant platelets differ in morphology and function from spread and aggregating platelets. Finally, morphologically and functionally distinct platelet subpopulations participate in the spatiotemporal regulation of hemostatic plug and thrombus formation.