Skip to main content

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence

52Citations
Citations of this article
71Readers
Mendeley users who have this article in their library.
Get full text
This PDF is freely available from an open access repository. It may not have been peer-reviewed.

Abstract

Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Δ9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P=0.05) and rs806380 (P=0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence. © 2008 Wiley-Liss, Inc.

Cite

CITATION STYLE

APA

Agrawal, A., Wetherill, L., Dick, D. M., Xuei, X., Hinrichs, A., Hesselbrock, V., … Foroud, T. (2009). Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 150(5), 736–740. https://doi.org/10.1002/ajmg.b.30881

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free