The communication between synapses and the cell nucleus has attracted considerable interest for many years. This interest is largely fueled by the idea that synapse-to-nucleus signaling might specifically induce the expression of genes that make long-term memory "stick." However, despite many years of research, it is still essentially unclear how synaptic signals are conveyed to the nucleus, and it remains to a large degree enigmatic how activity-induced gene expression feeds back to synaptic function. In this chapter, we will focus on the activity-dependent synapto-nuclear trafficking of protein messengers and discuss the underlying mechanisms of their retrograde transport and their supposed functional role in neuronal plasticity. © 2012 Springer-Verlag/WIen.
CITATION STYLE
Karpova, A., Bär, J., & Kreutz, M. R. (2012). Long-distance signaling from synapse to nucleus via protein messengers. Advances in Experimental Medicine and Biology, 970, 355–376. https://doi.org/10.1007/978-3-7091-0932-8_16
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