Structural and Surface Compatibility Study of Modified Electrospun Poly(ε-caprolactone) (PCL) Composites for Skin Tissue Engineering

179Citations
Citations of this article
217Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

In this study, biodegradable poly(ε-caprolactone) (PCL) nanofibers (PCL-NF), collagen-coated PCL nanofibers (Col-c-PCL), and titanium dioxide-incorporated PCL (TiO2-i-PCL) nanofibers were prepared by electrospinning technique to study the surface and structural compatibility of these scaffolds for skin tisuue engineering. Collagen coating over the PCL nanofibers was done by electrospinning process. Morphology of PCL nanofibers in electrospinning was investigated at different voltages and at different concentrations of PCL. The morphology, interaction between different materials, surface property, and presence of TiO2 were studied by scanning electron microscopy (SEM), Fourier transform IR spectroscopy (FTIR), contact angle measurement, energy dispersion X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). MTT assay and cell adhesion study were done to check biocompatibilty of these scaffolds. SEM study confirmed the formation of nanofibers without beads. FTIR proved presence of collagen on PCL scaffold, and contact angle study showed increment of hydrophilicity of Col-c-PCL and TiO2-i-PCL due to collagen coating and incorporation of TiO2, respectively. EDX and XPS studies revealed distribution of entrapped TiO2 at molecular level. MTT assay and cell adhesion study using L929 fibroblast cell line proved viability of cells with attachment of fibroblasts over the scaffold. Thus, in a nutshell, we can conclude from the outcomes of our investigational works that such composite can be considered as a tissue engineered construct for skin wound healing.

References Powered by Scopus

Electrospinning of nanofibers: Reinventing the wheel?

5270Citations
N/AReaders
Get full text

Porous scaffold design for tissue engineering

3464Citations
N/AReaders
Get full text

The design of scaffolds for use in tissue engineering. Part I. Traditional factors

2070Citations
N/AReaders
Get full text

Cited by Powered by Scopus

PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications

347Citations
N/AReaders
Get full text

Recent advancements in applications of chitosan-based biomaterials for skin tissue engineering

241Citations
N/AReaders
Get full text

Electrospinning tissue engineering and wound dressing scaffolds from polymer-titanium dioxide nanocomposites

225Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ghosal, K., Manakhov, A., Zajíčková, L., & Thomas, S. (2017). Structural and Surface Compatibility Study of Modified Electrospun Poly(ε-caprolactone) (PCL) Composites for Skin Tissue Engineering. AAPS PharmSciTech, 18(1), 72–81. https://doi.org/10.1208/s12249-016-0500-8

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 87

68%

Researcher 24

19%

Professor / Associate Prof. 11

9%

Lecturer / Post doc 6

5%

Readers' Discipline

Tooltip

Materials Science 32

34%

Engineering 27

28%

Biochemistry, Genetics and Molecular Bi... 22

23%

Chemistry 14

15%

Save time finding and organizing research with Mendeley

Sign up for free