Synthesis of chiral cyclobutanes via rhodium/diene-catalyzed asymmetric 1,4-addition: A dramatic ligand effect on the diastereoselectivity

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Abstract

A highly diastereo- and enantioselective rhodium-catalyzed arylation of cyclobutenes for the efficient synthesis of chiral cyclobutanes has been developed. Chiral diene ligands exhibited excellent capability for the reaction diastereoselectivity control.

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Chen, Y. J., Hu, T. J., Feng, C. G., & Lin, G. Q. (2015). Synthesis of chiral cyclobutanes via rhodium/diene-catalyzed asymmetric 1,4-addition: A dramatic ligand effect on the diastereoselectivity. Chemical Communications, 51(42), 8773–8776. https://doi.org/10.1039/c5cc02023a

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