Susceptibility testing of dermatophytes

Abstract

The dermatophytes are a specialized group of fungi which infect the keratinized tissues of humans (hair, nails, and skin) and cause superficial infections. While several studies have been conducted to develop methods to determine the susceptibilities of yeast and filamentous fungi, similar studies for dermatophytes have only recently taken place. In this chapter, we will review how susceptibility testing of dermatophytes was developed and how it has already been applied to clinical samples. With several agents now available for treating infections due to dermatophytes, susceptibility testing will serve as a valuable tool for clinicians as they choose the most appropriate treatment option. Studies are still needed to establish interpretive breakpoints for antifungal agents used in the treatment of superficial fungal infections.