Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases

93Citations
Citations of this article
106Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Cardiovascular disease (CVD) remains a leading cause of mortality worldwide despite advances in its prevention and management. A comprehensive understanding of factors which contribute to CVD is required in order to develop more effective treatment options. Dysregulation of epigenetic posttranscriptional modifications of histones in chromatin is thought to be associated with the pathology of many disease models, including CVD. Histone acetyltransferases (HATs) and deacetylases (HDACs) are regulators of histone lysine acetylation. Recent studies have implicated a fundamental role of reversible protein acetylation in the regulation of CVDs such as hypertension, pulmonary hypertension, diabetic cardiomyopathy, coronary artery disease, arrhythmia, and heart failure. This reversible acetylation is governed by enzymes that HATs add or HDACs remove acetyl groups respectively. New evidence has revealed that histone acetylation regulators blunt cardiovascular and related disease states in certain cellular processes including myocyte hypertrophy, apoptosis, fibrosis, oxidative stress, and inflammation. The accumulating evidence of the detrimental role of histone acetylation in cardiac disease combined with the cardioprotective role of histone acetylation regulators suggests that the use of histone acetylation regulators may serve as a novel approach to treating the millions of patients afflicted by cardiac diseases worldwide. © 2014 Yonggang Wang et al.

Cite

CITATION STYLE

APA

Wang, Y., Miao, X., Liu, Y., Li, F., Liu, Q., Sun, J., & Cai, L. (2014). Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases. Oxidative Medicine and Cellular Longevity. Landes Bioscience. https://doi.org/10.1155/2014/641979

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free