Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms.
CITATION STYLE
Yu, Q. (2008). Cancer gene silencing without DNA hypermethylation. Epigenetics : Official Journal of the DNA Methylation Society, 3(6), 315–317. https://doi.org/10.4161/epi.3.6.7202
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