The phases of LTP: The new complexities

Abstract

Conclusion: The work begun by John Sarvey on the biochemical processes involved in synaptic plasticity has progressed rapidly. The LTP field is now blessed with a great deal of data showing how the different phases of LTP and the synaptic weakening processes are affected by pharmacological and genetic perturbations. There is the feeling in the memory field that the cast of characters involved in LTP has been largely identified. These include second messenger cascades, kinases, phosphatases, channels, structural proteins, a vesicle delivery system, regulators of gene transcription and translation, and mediators of synaptic growth. The challenge ahead is to understand how this cast works together to make the play memorable.