Impact of subclinical hypothyroidism and thyroid autoimmunity on clinical pregnancy rate after intrauterine insemination in euthyroid women

Abstract

Objective: This study aimed to evaluate the association between subclinical hypothyroidism and thyroid autoantibodies with clinical pregnancy rate after intrauterine insemination (IUI) in euthyroid women. Methods: In this prospective cohort study, we recruited 497 women who underwent IUI treatment. We assessed thyroid function tests, thyroid antibodies and clinical pregnancy rates of the patients. Results: The patients were divided into two groups according to TSH values: Normal group, n=387, and subclinical hypothyroidism group 2, n=110. The clinical pregnancy rate was 15.2% in the Control Group and 17.3% in the study group (p=0.656). In the Study Group, 35% of the patients had anti-TPO positivity (p=0.531) and 42.1% of the patients had anti-TG positivity (p=0.285). There was no statistically significant difference in clinical pregnancy rates between the groups in terms of antithyroid antibody positivity (p=0.54; p=0.559, respectively). Conclusion: Anti-TPO antibodies and subclinical hypothyroidism had no impact on clinical pregnancy rates in the women submitted to IUI.