Cerebral cortical capillary basement membrane thickening in galactosaemic rats

Abstract

Wistar-Kyoto rats fed a diet containing 30% by weight galactose for 15-21 months developed significant thickening of the endothelial basement membranes of capillaries from the frontal cortex of the cerebrum, by comparison with cerebral capillary basement membranes from animals on a standard diet (p<0.001), or animals receiving a diet containing 30% galactose together with 250 mg/kg diet of the aldose reductase inhibitor, Sorbinil (0.001